ACTA1 and nemaline myopathy: The majority of P/LP variants (74%) cause nemaline myopathy (NEM3, now CMYP2A; OMIM#161800), followed by congenital fibre type disproportion (CFTD, now CMYP2C; OMIM #620278) at 7.2%, and intranuclear rod myopathy (IRM) at 4.3% (Supporting Information 1).