It is also seen in the prevalence of some rare genetic diseases (reviewed in [34]): familial hypercholesterolemia, hereditary breast and ovarian cancer syndrome, and long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency; steroid-resistant nephrotic syndrome caused by biallelic defect in the NPHS2 gene is another example. The gene discussed is NPHS2; the disease is Hereditary breast and ovarian cancer syndrome.