SETD1A and neurodevelopmental disorder: Most of the genetic loci highlighted by such CAS screens have also been implicated in heterogeneous neurodevelopmental disorders, in which speech problems may occur in the context of a more pervasive syndrome, with notable examples including CHD3 [16] (MIM: 618205), SETD1A [17] (MIM: 619056), WDR5 [18], and SETBP1 [19] (MIM: 616078).