CARD9 and clear cell renal carcinoma: Targets for clear cell renal cell carcinoma include the NF-κB agonists IκB kinase b and caspase recruitment domain protein 9 (CARD9), MAPK1, fibronectin, collagen IV, RpB1 (the large subunit of RNA polymerase II), human antigen R (HuR), and Akt (also known as protein kinase B)62.