Through the regulation of glucose-6-phosphate dehydrogenase (G6PD), carnitine palmitoyl transferase 1a (CPT1A), acyl-coenzyme A oxidase 1(ACOX1), NF-κB, and cell cycle protein activities, E3 Ub-protein ligase affects podocytes' function and plays a significant role in the development of DKD. Here, CPT1A is linked to diabetic kidney disease.