Besides, KEGG analysis revealed that Base excision repair is one of the pathways involved in the DNA damage repair process, and cell_cycle regulation has an impact associated with cell proliferation similar to the effect of E2F targets or the G2M checkpoint mentioned above which might support ANKRD22 in the process of tumorigenesis in PC (Fig. 4B). This evidence concerns the gene ANKRD22 and pachyonychia congenita.