While inherited mutations—such as mismatch repair gene mutations in Lynch syndrome, TP53 gene in Li–Fraumeni syndrome, and APC gene in familial adenomatous polyposis—increase susceptibility to multiple malignancies [4, 5], breast cancer is not typically associated with HNPCC, and our patient did not meet the Amsterdam II criteria for Lynch syndrome. This evidence concerns the gene TP53 and Familial adenomatous polyposis.