Independent baseline risk factors associated with all-cause mortality/HTx in young adult patients with DCM included smoking (HR 2.339, p =0.008), digoxin use (HR 2.535, p = 0.031), elevated levels of NT-proBNP (≥ 5678 pg/mL, HR 2.284, p = 0.032), CRP (≥ 3.0 mg/L, HR 5.654, p < 0.001), UA (≥ 570 μmol/L, HR 1.928, p = 0.074), lower LVEF (≤ 25%, HR 2.370, p = 0.011), and larger LVD (≥ 65 mm, HR 2.110, p = 0.045). This evidence concerns the gene NPPB and familial dilated cardiomyopathy.