These results showed that CCN1 inhibition also significantly reduced the expression of p-ERK/ERK, p-P38/P38, and p-JNK/JNK in cardiomyocytes caused by CKD (Figures 6(a), 6(b), 6(c), 6(d), 6(e), and 6(f)). The gene discussed is MAPK8; the disease is chronic kidney disease.