CCN1 and chronic kidney disease: As a result, compared with the WT or CCN1−/− groups, serum creatinine and serum urea nitrogen were significantly increased in CKD group and the CCN1−/− + CKD group, and compared with the WT or CKD groups, there was no significant difference in CCN1−/− groups or CCN1−/− + CKD group (Figures 3(a) and 3(b)), indicating that the renal function of 5/6 Nx mice was markedly reduced and that specific CCN1−/− had no influence on kidney function.