Using a caerulein-independent PDL model of AP, administration of LRG1 neutralizing antibody induced CCK1R expression (Supplementary Figure S8C), improved overall pancreatic structure and function, as evidenced by H&E staining (Supplementary Figure S8D), reduced histopathological scores for overall damage (Supplementary Figure S8E) and increased pancreatic Amy2 mRNA levels (Supplementary Figure S8F). This evidence concerns the gene CCKAR and alkaline phosphatase measurement.