Substantial acinar cell death and inflammatory cell infiltration, hallmarks of AP, were evident 24 hours after PDL (Supplementary Figure S3A), which was accompanied by concurrent increases in serum (Supplementary Figure S3B) and pancreatic LRG1 mRNA (Supplementary Figure S3C) and protein (Supplementary Figure S3D) levels. Here, LRG1 is linked to alkaline phosphatase measurement.