We found that serum LRG1 levels were significantly elevated in individuals with AP compared to healthy controls (Figure 2A) and were closely associated with C-reactive protein (CRP) (Figure 2B), neutrophil levels (Supplementary Figure S2A) and serum lipase (Supplementary Figure S2B), important biomarkers for predicting AP severity, SIRS and MODS 32, 33. Here, LRG1 is linked to systemic inflammatory response syndrome.