We further showed that LRG1 served as a direct target gene of the IL-6/STAT3 pathway and LRG1 regulated the expression of the trophic gene CCK1R by regulating the non-canonical TGFβ/Akt signalling in acinar cells, which not only explains the more severe pancreatic injury following caerulein-induced AP but also the accelerated recovery of AP in Lrg1-/- mice. This evidence concerns the gene CCKAR and alkaline phosphatase measurement.