Histopathological analysis performed 24 hours later revealed that L364,718 significantly attenuated the severity of AP in Lrg1-/- mice, as evidenced by decreased acinar cell loss, inflammatory cell infiltration, and interstitial edema based on H&E staining (Figure 8B) and histopathological scoring (Figure 8C). Here, LRG1 is linked to alkaline phosphatase measurement.