CRP and systemic inflammatory response syndrome: We found that serum LRG1 levels were significantly elevated in individuals with AP compared to healthy controls (Figure 2A) and were closely associated with C-reactive protein (CRP) (Figure 2B), neutrophil levels (Supplementary Figure S2A) and serum lipase (Supplementary Figure S2B), important biomarkers for predicting AP severity, SIRS and MODS 32, 33.