Using a caerulein-independent PDL model of AP, administration of LRG1 neutralizing antibody induced CCK1R expression (Supplementary Figure S8C), improved overall pancreatic structure and function, as evidenced by H&E staining (Supplementary Figure S8D), reduced histopathological scores for overall damage (Supplementary Figure S8E) and increased pancreatic Amy2 mRNA levels (Supplementary Figure S8F). Here, LRG1 is linked to alkaline phosphatase measurement.