Peptides like [18F]AFP-SWL, [99mTc]-HYNIC-SWL and [68Ga]DOTA-SD01 24 have shown specificity for detecting EphA2 expression in melanoma, non-small cell lung and breast cancers but suffered from degradation in plasma and low tumor uptake limiting their application 22, 23. The gene discussed is AFP; the disease is breast cancer.