SFRP1 and colorectal carcinoma: Additionally, IHC analysis of CRC tissues revealed upregulated expression of proliferation markers Ki67, as well as EMT markers N-cadherin, Vimentin, Snail, Zeb1, and N-cadherin, with a concomitant decrease in E-cadherin expression in the CAF-Sfrp1 group (Figure 6P).