USP11 and pulmonary fibrosis: Additionally, hiPSCs-SFTPCI73T-AOs treated with TGF-β had a higher collagen gel contraction compared to the wild-type SFTPC, while blocking USP11 with MTX reversed that phenotype (Figure 7B), indicating that USP11 inhibition lowers SFTPCI73T-driven pulmonary fibrosis.