MKI67 and neoplasm: The additional site comparing to the 2SX model used in cell culture measurements is the vascular component in vivo. The kio map (Figure 4E) and Ki67 expression of the corresponding slices showed similar spatial distributions on visual inspection, e.g., in Figure 4E, F higher kio together with greater Ki67 expression in the tumor margin (yellow rectangle) was observed and vice versa (green rectangle).