FOS and mood disorder: Based on the results of the fMRI and previous studies, we examined the Fos-CreER::Ai9 positive neurons in brain regions associated with pain and mood disorders, including the BLA, ACC, medial prefrontal cortex (mPFC), insular cortex (IC), lateral habenula (LHb), ventral hippocampus (vHIP), and paraventricular nucleus of the thalamus (PVT).