Researchers have developed a kind of nanoparticles encapsulating the photosensitizer and CD39 inhibitor ARL67156, where, upon laser irradiation, nanoparticle-produced ROS induce ATP release from tumor cells and trigger the cleavage of nanoparticle and the release of ARL67156 from the nanoparticles 131. Here, ENTPD1 is linked to neoplasm.