METTL14 and cancer: Particularly in cancer, for instance, in colorectal cancer (CRC), the removal of the H3K4me3 mark downregulates METTL14, reducing m6A accumulation on SOX4 mRNA, protecting it from degradation by YTHDF2, and leading to enhanced migration of CRC cells and SOX4-mediated epithelial-mesenchymal transition 73.