STMN1 and colorectal carcinoma: Overexpression of STMN1 reduced the frequency of homotypic CIC structures (Figure 5C) and reduced the proportion of CIC structures in which SDCSCs serve as the outer cells; instead, the proportion of CIC structures with the reverse configuration, i.e., SDCSCs serving as the inner cells wrapped around parental CRC cells, increased (Figure 5D-E).