In the meantime, to improve the rate of transfection of the shRNA-Ptpn2 plasmid, tumor-homing peptides iRGD and branching poly-ethylenimine (PEI) were employed to compact shRNA-Ptpn2 and create a complex (shRNA-PEI-iRGD, RPR) as shown in Figure 7B. This RPR surface is electrostatically coated with HA-DOX (HD), resulting in HD@RPR. This evidence concerns the gene PTPN2 and neoplasm.