The CIP model showed significant downregulation of brain A1 expression relative to controls ((1.01±0.01 vs. 1.06±0.01) (F (8, 45) = 56.60, Ρ < 0.0001)) (Figure 5a) and a significant upregulation of brain A2A ((1.09±0.01 vs. 0.91±0.05) (t (9) = 32.90, Ρ < 0.01)) (Figure 5b). This evidence concerns the gene IGKV2D-29 and hereditary sensory and autonomic neuropathy.