Both DE and BM+DE downregulated brain PAR1 expression compared to the untreated CIP model ((0.76±0.16 and 0.72±0.11, respectively) (t (9) = 46.47, Ρ < 0.05, t (9) = 46.47, Ρ < 0.01, respectively)), restoring it to control levels. Here, F2R is linked to hereditary sensory and autonomic neuropathy.