Both DE and BM+DE reduced brain ET1 levels compared to the untreated CIP model ((222.14±1.42 and 216.32±2.41, respectively) (t (9) = 44.48, Ρ < 0.001, t (9) = 44.48, Ρ < 0.0001, respectively)), restoring it to control levels. Here, EDN1 is linked to hereditary sensory and autonomic neuropathy.