The CIP model significantly upregulated brain PAR1 expression compared to control levels ((4.06±0.04 vs. 0.79±0.15) (t (9) = 46.47, Ρ < 0.05)) (Figure 6), together with increasing brain ET1 levels ((821.64±70.38 against 233.5±3.16) (t (9) = 44.48, Ρ < 0.05)) (Figure 7). Here, F2R is linked to hereditary sensory and autonomic neuropathy.