Additionally, when glaucoma patients were analyzed together, SMV density measurements showed that AI, AI-UH, paf-UH, paf-T, paf-S, paf-N, pef, pef-UH, pef-T, and pef-N vessel densities were lower in advanced-stage POAG eyes compared to early-stage eyes (all p<0.05). The gene discussed is PCLAF; the disease is glaucoma.