Von Willebrand disease (VWD) type I, a disorder caused by a deficiency of Von Willebrand factor (VWF), can lead to prolonged blood clotting times. This case report demonstrates the successful management of bilateral CMC joint osteoarthritis in a patient with VWD type I using arthroplasty, emphasizing the importance of perioperative hematological management to prevent complications. Here, VWF is linked to platelet-type von Willebrand disease.