ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; CAD, coronary artery disease; CHF, congestive heart failure; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; SCr, serum creatinine; TAVR, transcatheter aortic valve replacement. The gene discussed is ACE; the disease is congestive heart failure.