Cholangiocarcinoma, metastasis, and HCC stain negative for CD31, CD34, and factor VIII, and HCC stains positive for cluster of differentiation-10 (CD10), arginase, and hepatocyte paraffin 1 (HepPar-1) with polyclonal carcinoembryonic antigen [6]. The gene discussed is CD34; the disease is hepatocellular carcinoma.