The increased SESN2 levels in the PCOS group were associated with various metabolic disturbances such as dyslipidemia (low HDL, high LDL, and elevated triglycerides), insulin resistance, and a higher waist-to-hip ratio, which are key risk factors for cardiovascular diseases and metabolic syndrome in PCOS patients. This evidence concerns the gene SESN2 and polycystic ovary syndrome.