In women with PCOS, the dysregulation of autophagy has been observed in the endometrium and ovarian granulosa cells and is regulated by various proteins, including SESN2. Two primary mechanisms have been identified for SESN2's protective function: first, SESN2 acts as an antioxidant, reducing excessive reactive oxygen species. The gene discussed is SESN2; the disease is polycystic ovary syndrome.