In another study by Çatal and Kovalak, serum SESN2 levels were significantly lower in the obese PCOS group compared to both the control and non-obese PCOS groups (P=0.001 and P=0.0001), with the non-obese PCOS group also showing significantly lower SESN2 levels compared to the control group (P=0.0001) [18]. This evidence concerns the gene SESN2 and polycystic ovary syndrome.