SESN2 and polycystic ovary syndrome: In a similar context, Bestel et al. conducted ROC analysis and found that serum SESN2 levels were strong indicators for diagnosing PCOS, with an impressive AUC of 99.4% at a cutoff value of 4.69 ng/mL (P<0.001; 95% CI: 96.4%-100%; sensitivity: 100%; specificity: 96.7%) [29].