Adamantinoma-like Ewing sarcoma (ALES) is an uncommon tumor now recognized as a variant of ES due to its similar round cell structure, CD99 (MIC2) and NKX2.2 immunoreactivity, along with its complex epithelial differentiation, defined by the t(11;22) EWSR1::FLI1 gene fusion [5-8]. This evidence concerns the gene CD99 and Ewing sarcoma.