In another study using NOD1/NOD2 double knockout mice, it was reported that the NOD double knockout mice had higher anxiety-like behavior and worsened performance on cognitive tests like novel object recognition after stress [29], further implicating the role of NOD-signaling and RIPK2 in neuronal survival, anxiety-like behavior, and cognitive impairment. This evidence concerns the gene NOD2 and Cognitive impairment.