The median (interquartile range [IQR]) PlGF (pg/ml) was significantly higher in the serum of patients with SSc-SRC+ (42.1 [21.4–51.8]) compared with donors (14.7 [11.8–17.9]), those with SSc-SRC− (18.5 [14.7–21.5]) (P < 0.0001), those with HUS (22.8 [19.5–29.6]), and those with MHT (25.5 [17.2–39.3]) (P < 0.0001). The gene discussed is SRC; the disease is malignant hypertension.