IL17A and experimental autoimmune encephalomyelitis: An in vivo study on the effects of methadone on experimental autoimmune encephalomyelitis (EAE) revealed a reduction in Th1 and T helper 17 (Th17) cell infiltration in the spinal cord, as well as a decrease in levels of IL-2, interleukin-17 (IL-17), IFN-γ, and IL-6 in the serum.