Recently, this study showed that using a DSS-induced zebrafish IBD model revealed chrysanthemum morifolium extracts significantly improved IBD pathology, while L. japonicas bioactive metabolites, including Isochlorogenic acid C, Isochlorogenic acid A (ICA A), other phenolic acids, flavonoids, and polysaccharides, reduced IL-1β, IL-8, and MMP9 expressions, demonstrating notable anti-inflammatory and antioxidant effects (156). This evidence concerns the gene CXCL8 and irritable bowel syndrome.