NLRP3 and colitis: Similarly, in this study, quercetin-loaded silk fibroin nanoparticles (QSFN) demonstrate significant anti-inflammatory effects in a mouse model of colitis by inhibiting the NLRP3 inflammasome and reducing pro-inflammatory cytokines like IL-1β, suggesting QSFN as a promising treatment for IBD, where quercetin alone was ineffective due to poor bioavailability and stability (201).