Additionally, another study has shown that caffeic acid phenethyl ester (CAPE), a honeysuckle metabolite of phenolic acid with anti-inflammatory properties, can suppress NLRP3 activation, decrease ROS production, and promote NLRP3 ubiquitination, thus protecting against AOM/DSS-induced colorectal cancer in mice (59). Here, NLRP3 is linked to colorectal cancer.