Inflammatory molecules and immune factors are expressed at different stages of T2DM development, including high-sensitivity C-reactive protein (hs-CRP), immunoglobulin (Ig) E, tumor necrosis factor-α (TNF-α), interleukins (ILs), leptin, adiponectin, monocyte chemoattractant-1 (MCP-1), and plasminogen activator inhibitor-1 (PAI-1) (11–15). This evidence concerns the gene TNF and type 2 diabetes mellitus.