A recent meta-analysis including 33 studies reported that the estimated prevalences of non-fibrosis, significant fibrosis, advanced fibrosis, and cirrhosis for HBeAg-positive ALT-normal CHB were 31.2%, 16.9%, 5.4%, and 0.0% and for HBeAg-negative ALT-normal CHB were 32.4%, 24.8%, 3.0% and 0.0%, respectively [23]. The gene discussed is GPT; the disease is Cirrhosis.