The “ferroportin score” very recently proposed by Landemaine et al. to increase the proficiency of genetic testing for FD [69] could conceivably also be used to better distinguish pathogenic loss-of-function mutations from neutral rare variants identified by chance in patients with a secondary (but perhaps not clearly defined) cause of hyperferritinemia; we could not test this score because of the piecemeal information available in the literature (only 9 patients for whom the 5 considered criteria could have been reliably used). Here, SLC40A1 is linked to isolated hyperferritinemia.