The existence of an adult, autosomal dominant primary iron overload, soon regarded as an atypical form of hemochromatosis (HC) and now also referred to as ferroportin disease (FD) [13], was based on the description of two SLC40A1 missense mutations, namely, p.Ala77Asp and p.Asn144His, in Italian and Dutch pedigrees [14, 15]. This evidence concerns the gene SLC40A1 and hemochromatosis.