ERLIN2 and hereditary spastic paraplegia: To study the pathogenesis of HSP caused by the ERLIN2 p.Val71Ala variant, we used reprogramming techniques to edit patients (iPS-GJH and iPS-YCY) and normal controls (iPSC-GDL) in the family line, and after karyotype analysis and pluripotency verification, we obtained mature iPS cell lines (Supplementary Figure S2).