GNAO1 and infantile spasms: Most of the GNAO1-DEE patients present either EIDEE, which includes the Ohtahara syndrome that was originally linked to the GNAO1 disorder [1] and is hallmarked by a burst suppression pattern on an electroencephalogram (EEG) and tonic seizures, or IESS that is also known as West syndrome with hypsarrythmia on EGG (Figure 4(a)).