SOD1 and amyotrophic lateral sclerosis: Notably, heritability estimates for ALS are high [2], and mutations known to cause the disease in patients with a family history, including pathogenic variants in C9orf72 (recurring hexanucleotide repeat expansion; [MIM: 614260]), SOD1 [MIM: 147450], TARDBP [MIM: 605078], and FUS [MIM: 13707], have been frequently observed in apparently sporadic patients as well [3–5].