We observed that the REVEL scores for the four ALS-associated genes with the lowest Z score—SPG11 (Z = −1.39), SQSTM1 (Z = −0.94), ANXA11 (Z = −0.25), and GRN (Z = 0.28)—were lower, on average, than the REVEL scores for the four ALS-associated genes with the highest Z score—TUBA4A (Z = 3.3), KIF5A (Z = 3.6), TARDBP (Z = 3.71), and VCP (Z = 5.41). This evidence concerns the gene SPG11 and amyotrophic lateral sclerosis.