Sarcoglycanopathies are caused by mutations which occur in LGMD genes SGCA, SGCB, SGCG, and SGCD that lead to misfolding, truncated, or loss of protein of α, β, γ, and δ protein which stabilizes the sarcolemma of muscle cells. The gene discussed is SGCG; the disease is limb-girdle muscular dystrophy.