RARB has previously been identified in gene regulatory network of osteosarcoma (Luo et al., 2013), whereas FOXC1 (together with FOXC2) was shown to direct hypertrophic chondrocyte maturation and function toward primary ossification center formation and osteoblast recruitment (Almubarak et al., 2024). The gene discussed is RARB; the disease is osteosarcoma.