The results showed that hypertension (p=0.025, 95% confidence interval (CI):1.143–7.070), serum albumin (p=0.001, 95% CI: 0.77–0.936), SOFA score (p=0.004, 95% CI: 1.083–1.533), tidal volume (p < 0.001, 95% CI: 0.986–0.995), and respiratory rate (p < 0.001, 95% CI: 1.169–1.415) were independent risk factors for weaning failure in critically ill patients at high altitude (Table 3). This evidence concerns the gene ALB and hypertensive disorder.