Results: The MR analysis revealed significant associations between HMGCR inhibition and increased risks of diabetic nephropathy (OR [95%confidence interval (CI)] = 1.88 [1.50, 2.36], p = 5.55 × 10–8), retinopathy (OR [95%CI] = 1.86 [1.54, 2.24], p = 6.28 × 10–11), and neuropathy (OR [95%CI] = 2.63 [1.84, 3.75], p = 1.14 × 10–7) using the inverse variance weighted method. The gene discussed is HMGCR; the disease is diabetic kidney disease.