Current studies have shown that the methylation of NLRP3, AIM2, ASC, ABCG1, TXNIP, SREBF1, and other genes is significantly correlated with T2DM, among which the methylation of ABCG1 is the strongest associated with T2DM [46, 47]. The gene discussed is ABCG1; the disease is type 2 diabetes mellitus.