INS and type 2 diabetes mellitus: A subsequent study in 2016 showed that the methylation level at cg06500161 of the ABCG1 gene was associated with an increased risk of T2DM (OR = 1.09, 95% CI: 1.02–1.16), and that the methylation level at this site was positively correlated with BMI, HbAlc, fasting insulin, and TG levels [49].