After adjusting for smoking, alcohol consumption, exercise, hypertension, obesity, dyslipidemia, and FPG, there was a statistically significant association between the methylation level of the ABCG1 gene locus and the risk of T2DM (p = 0.015, OR: 1.023; 95% CI: 1.004~1.041). This evidence concerns the gene ABCG1 and obesity disorder.