Generalized multifactor dimensionality reduction (GMDR) showed that the rs7901695 locus of the TCF7L2 gene and the cg06500161 locus of the ABCG1 gene had interaction with hypertension, dyslipidemia, abdominal obesity, and obesity and also had interaction with drinking, smoking, and exercise. This evidence concerns the gene ABCG1 and obesity due to melanocortin 4 receptor deficiency.