After adjusting for covariates (smoking, alcohol consumption, exercise, fasting blood glucose (FPG), obesity, and hypertension), the genotype of rs7901695 in the TCF7L2 gene was associated with genetic susceptibility to T2DM in additive (TC vs. TT,p = 0.047; CC vs. TT,p = 0.010), dominant (p = 0.015), and recessive (p = 0.039) models. This evidence concerns the gene TCF7L2 and obesity disorder.