Recent work suggests that COMP and CILP2 are markers of a highly differentiated fibroblast stage named a matrifibrocyte in postmyocardial infarction scarring, cells that are highly differentiated towards matrix production in highly collagenous environments, suggesting that increased COMP and CILP2 could represent greater neomatrix maturity [100]. The gene discussed is CILP2; the disease is infarction.