Equally important was that logistic regression manifested increased levels of inflammatory mediators (IL-8, IL-17, and s-100β), nodal efficiency of the right amygdala nodal network, and the intensity of the prefrontal-cingulate-amygdala subnetwork were risk factors for UD, while the high anxiety symptom was a risk factor for BD. This evidence concerns the gene S100B and Behcet disease.