SREBF1 and metabolic dysfunction-associated steatotic liver disease: IR conditions lead to overexpression of SREBP-1 (sterol regulatory element binding protein-1), which triggers upregulation of de novo lipogenesis (DNL), resulting in Impaired inhibition of lipolysis in adipose tissue (AT) and the production of large amounts of free fatty acids, which eventually accumulate in the liver and kidney [24], further aggravating NAFLD.