In a bile duct ligation (BDL) mouse model of liver fibrosis, Rhbdf2-/-BDL mice were found to have reduced ADAM17 activation and TNFR shedding following BDL, suggesting an increase in unbound TNFR on the surface of hepatic stellate cells or hepatocytes, promoting TNF-α binding to TNFR and driving hepatic stellate cell growth and liver fibrosis [73]. Here, RHBDF2 is linked to Hepatic fibrosis.