Numerous immune diseases are closely associated with the pathogenesis of GRK2, which regulates immune function (Figure 3), including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), SS, and multiple sclerosis (MS), autoimmune cardiomyopathy, autoimmune hepatitis (AIH), Graves, etc. GRK2 is thought to be a popular target for these diseases [32, 33]. Here, GRK2 is linked to inflammatory bowel disease.