It has also been found that the increase in the expression frequency of p53, the hypermethylation level of CpG islands of some genes such as mMLH1, and the activation of many cytokine pathways such as IL-6 and IL-11 are closely related to the occurrence of CRC in UC patients, which have not been observed in CD patients [39]. This evidence concerns the gene IL11 and colorectal carcinoma.