In a study of 13 children and 7 adolescents with VWD receiving prophylaxis with Haemate-P or wilate, recurrent BEs stopped in all of the patients except for one 7-year-old patient with type 3 VWD who developed VWF inhibitors after 48 exposure days to Haemate-P [8]. This evidence concerns the gene VWF and von Willebrand disease 3.