CYP27A1 and bone metastasis: Additionally, when comparing bone metabolism markers among the groups, those with tumor bone metastasis displayed significantly higher levels of NMID (p = 3.46 × 10−15), TPINP (p = 3.16 × 10−10), and β-CTX (p = 5.00 × 10−12) than both the group without bone metastasis and the control group (Figures 1D–F).