For example, the miR-17-92 cluster (11), including miR-17 and miR-20a, has been implicated in modulating the TGF-β signaling pathway by targeting SMAD2, SMAD4, and TGFBR2, contributing to cancer progression, and miR-26a (12) has been identified as a tumor suppressor in multiple cancers, including hepatocellular carcinoma, by directly targeting Cyclin D2 and Cyclin E2, leading to G1 phase cell cycle arrest. This evidence concerns the gene TGFBR2 and cancer.