AKT1 and cancer: In colorectal cancer, miR-146b has been shown to regulate cancer cell proliferation and invasion, similarly enhancing the transcription of Cyclin D1 and other cell cycle regulators through its modulation of key signaling pathway state cancer; miR-146b also promotes cell growth by targeting PTEN and activating the PI3K/AKT pathway, which can intersect with the mechanisms we can observe in bladder cancer.