Similarly, the recent identification of p. Gly161Ser variant by Xie et al. highlighted the potential impact of specific mutations on the selectivity filter motif of the ClC-2 channel, which could alter its function and implicate CLCN2 more directly in the pathophysiology of IGE (Xie et al., 2019). Here, CLCN2 is linked to idiopathic generalized epilepsy.