CLCN2 and idiopathic generalized epilepsy: Additionally, several large-scale studies have failed to detect significant CLCN2 mutations in cohorts of patients with IGE or other epilepsy syndromes (Blanz et al., 2007; Everett et al., 2007; Stogmann et al., 2006), and the causal role of CLCN2 mutations has been questioned by several authors, further complicating our understanding of the role of the gene in epilepsy.